In the light of previous reports which mainly found decreased CSF TTR levels in disorders that are not primarily associated with inflammation (i.e., depression [43], AD [14], [24] and amyotrophic lateral sclerosis [44]), but increased levels in disorders typically associated with inflammatory processes (such as Guillain Barré syndrome and chronic inflammatory demyelinating polyneuropathy [45]–[47]) it may be interesting to focus in future studies on putative interaction pathways between inflammation and TTR in Asyn-associated pathology. The gene discussed is TTR; the disease is depressive disorder.