Though EZH2 levels are known to significantly correlate with negative ER status, negative PR status, lymph node status, and tumor cell proliferation [6], [8], [11], and HOTAIR levels correlate with eventual metastasis and death [17], other clinicopathologic correlations between HOTAIR and the other two lncRNAs (ncHoxA1 and ncHoxD4) are unknown. The gene discussed is ESR1; the disease is neoplasm.