Although the sample size is small (only 50 cases followed by active expectancy with Gleason scores 8–10 were scored for both tumour pAkt-IR and Ki67-IR), the finding that pAkt-IR does not provide additional prognostic information when Ki67-IR (expressed as the number of positive stained cells crossing 11 horizontal lines across the core) is taken into account (Table S3) is consistent with the suggestion that the prognostic significance of pAkt-IR per se in Gleason score cases 8–10 is related to the proliferative capacity of the cells with high pAkt-IR expression. The gene discussed is MKI67; the disease is neoplasm.