These include the cp26-encoded proteins ResT (telomere resolvase, required for linear chromosome and plasmid replication) [15], [16], OspC (outer surface protein C, required for early mammalian infection) [17]–[21], and BBB26/BBB27 (homologous proteins with an unknown function essential for in vitro survival that cross-complement one another) [15], [16]. Here, CYP26A1 is linked to infection.