NK cell mediated tumor cell lysis is dependent on the expression of so called danger/stranger signaling molecules on target cells such as the NKG2D ligands major histocompatibility complex I class related (MIC)-A, MIC-B, or UL16 binding proteins (ULBP) 1, 2, 3, or the DNAX accessory molecule-(DNAM)-1 ligands CD112 and CD115. The gene discussed is MICA; the disease is neoplasm.