The immune stimulating effect of ISCADOR might be, on the one hand, an effect of reduced secretion of the prominent immunosuppressive cytokine TGF-β [4, 5, 58] in ISCADOR treated GBM cells, on the other hand might result from the strengthened attachment of NK cells to the surface of ISCADOR treated GBM cells, by this mechanism forcing the contact between immune effector and tumor target cells. The gene discussed is TGFB1; the disease is neoplasm.