In contrast to ISCADOR mediated enhancement of NK cell activity, cocultivation of LNT-229 glioma cells with purified and activated T cells did not show any difference in the lysis of untreated compared to ISCADOR treated glioma cells, also no changes in the cell surface expression of MHC molecules were detectable on LNT-229 cells if these cells were treated with ISCADOR (data not shown). The gene discussed is HLA-C; the disease is glioma.