The secretion of two additional factors related to tumor growth and motility as well as to angiogenesis, was also decreased in ISCADOR Q treated GBM cell: VEGF, whose expression is known in GBM to be correlated with MMP-2 [54] and Angiopoietin-1, a factor suggested to regulate, beside angiogenesis, GBM cell adhesion to the ECM via its receptor Tie-2 [55]. This evidence concerns the gene MMP2 and neoplasm.