Since it has been described that the net MMP-2 activity correlates with the level of TIMP-2 expression [50], and knowing that under certain conditions TIMP-2 can activate MMP-2 [51], we analyzed TIMP-2 protein expression, demonstrating that TIMP-2 is also downregulated in ISCADOR treated GBM cells (Figure 6(a)). The gene discussed is TIMP2; the disease is glioblastoma.