BIRC5 and central nervous system cancer: As shown in Figure 1(a), treatment of glioma cells with ISCADOR Q reduced the expression of a variety of genes relevant for gliomagenesis: epidermal growth factor receptor 2 (EGFR2/HER2/ERBB2) stimulates proliferation and blocks apoptosis [44], whereas BIRC5/Survivin is a potent inhibitor of apoptosis [45].