The identification of CRT homologs in other parasites such as Onchocerca, Schistosoma, and Leishmania (Michalak et al., 1992; Nash et al., 1994; Joshi et al., 1996) suggests that the protein functions as an intracellular chaperone but its role in the process of infection of those parasites remains unknown. Here, CALR is linked to infection.