With respect to this topic, a meta-analysis based on 38 studies involving 34,782 cases of PC and 38,626 controls, suggested that the SNP of the CYP17 gene, rs743572, may be significantly associated with the risk of PC in the Black population (but not in Caucasian and Asian; Wang et al., 2011). The gene discussed is CYP17A1; the disease is pachyonychia congenita.