It is strengthened further by those which show that the CRY2 gene expression is abnormal when inbred-strain mice with the intrinsic level of high anxiety are deprived of sleep (Wisor et al., 2008), and when humans with bipolar type 1 disorder do remain depressed after the antidepressant sleep deprivation (Lavebratt et al., 2010). The gene discussed is CRY2; the disease is Anxiety.