While we can not completely exclude the possibility that DNAJB6 may affect the HCMV DNA replication and infection by interacting with HCMV proteins other than UL70, our results that modulation of the expression of DNAJB6 leads to the same changes in the cellular localization of UL70 in mock-infected cells as in HCMV-infected cells (e.g. Figure 3, Figure 6, Figure S4, and Table S1 in Text S1) suggest that DNAJB6 may interact with UL70 and alters its cellular localization in the absence of other HCMV proteins, possibly leading to a modulation of viral DNA replication during HCMV infection. This evidence concerns the gene DNAJB6 and cytomegalovirus infection.