In the present study we did not find evidence for a role for MRP8/14 in chemotaxis: MPO levels in whole lung homogenates and the number of Ly-6G positive cells in lung tissue slides were not affected by the loss of MRP8/14 in spite of reduced levels of the neutrophil attracting chemokine MIP-2 early after infection. The gene discussed is S100A8; the disease is infection.