Thus, in the present study we aimed to determine the role of MRP8/14 during gram-negative sepsis originating from the lungs, using an established clinically relevant pneumonia model characterized by gradual growth of bacteria at the primary site of infection followed by dissemination, tissue injury and death [36]–[38], allowing to study a potential role of MRP8/14 in both the initial immune response as well as the subsequent harmful systemic inflammation phase. Here, S100A8 is linked to pneumonia.