When C3H/HeJ mice were infected with the Leptospira interrogans serovar icterohemorrhagiae, they presented with a lethal infection with morphological changes in the kidney and lungs [89] as well as sustained expression of CCL2/MCP-1 and CXCL1/KC in the lungs, which were correlated to the severity and progression of disease [90]. Here, CCL2 is linked to infection.