MED12 and leiomyosarcoma: Two MED12 mutations were detected in histopathologically confirmed early-onset (dg⩽45 years) uterine leiomyosarcomas; one affecting the codon 44 that is frequently mutated in uterine leiomyomas (c.130G>A, p.Gly44Ser) and the other inserting 21 nucleotides and leading to an in-frame transcript (c.115_116ins21, p.Ala38_Leu39ins7).