In each of the tumors in which MMTV activated Sdc2 or Phf19; MMTV also activated Wnt1, Fezf1, Sfmbt2, Ddn, Rspo2, Rspo3 or Fgf3. Similarly Kim et al. [10] have shown that Tcf7l2, Antxr1/Tem8 and Arhgap18 MMTV CIS, which appear at a low frequency, confer on cells altered growth kinetics and morphological transformation in three dimensional culture and occur in mammary tumors having multiple MMTV CIS. Here, RSPO2 is linked to breast cancer.