A number of proto-oncogenes have been shown to be recurrent targets of aSHM in DLBCL (i.e. BCL6, MYC, RHOH/TTF, PIM1, PAX5 [2, 12], IRF4, ST6GAL1, BCL7A, CIITA, LRMP [17], BCL2 [18], and SOCS1 [19]). The gene discussed is PIM1; the disease is diffuse large B-cell lymphoma.