The facts that PCA3 is expressed in higher levels in the androgen-responsive cell line (LNCaP) and that some ncRNA expressed in PCa cells are involved in the AR signaling [24,29,30] led us to hypothesize that PCA3 ncRNA expression may also be modulated by this pathway, and that this transcript may also be involved in the control of genes related to this cell signaling. The gene discussed is AR; the disease is posterior cortical atrophy.