A systematic Cochrane review of randomized clinical trials in T2DM patients found that, compared with NPH insulin, the risk of experiencing a severe hypoglycaemic episode was 30% lower with IGlar and 50% lower with IDet, the risk of experiencing of a nocturnal hypoglycaemic episode was 34% lower with IGlar and 37% lower with IDet, and the risk of experiencing any hypoglycaemic episode was 18% lower with IDet 29. This evidence concerns the gene INS and type 2 diabetes mellitus.