Finally, taking into account that there is evidence to suggest [52] that dietary fiber could modify the association between the FTO rs9939609 and obesity risk and considering that folate intake is strongly correlated with fiber intake (rho=0.801; P<0.001 in this population), we have adjusted the effects of folate for total fiber intake (as continuous in g/d). The gene discussed is FTO; the disease is obesity due to melanocortin 4 receptor deficiency.