When we considered the aggregate genetic score (score-grouped) as a categorical variable, individuals carrying 3 or 4 variant alleles for the FTO rs9939609 and the MC4R rs17782313 polymorphisms had 45% higher odds (P=0.009) of prevalent type 2 diabetes (OR: 1.45; 95%CI:1.09-1.92) than subjects with no risk alleles if their adherence to the MedDiet was low. Here, FTO is linked to type 2 diabetes mellitus.