When adherence to the MedDiet was low (=<9 points), carriers of the variant allele (obesity-risk allele) had a higher risk of prevalent type 2 diabetes (OR=1.21, 95%CI: 1.03-1.40; P=0.019 for FTO and OR=1.17, 95%CI:1.01-1-36; P=0.035 for MC4R) than homozygous subjects for the major allele. Here, MC4R is linked to obesity due to melanocortin 4 receptor deficiency.