Increased BP and reduced angiogenesis are expected to precipitate the evolution of the heart failure phenotype after myocardial damage.17,37 Indeed, 8 weeks after myocardial cryoinfarction, CaMK4−/− mice presented larger LV dilatation and a greater decrease in cardiac function than did CAMK4+/+ mice, as shown in both Table 3 and Figure 5A. This feature also was accompanied by reduced capillary density in the peri-infarct area (Figure 5B and 5C). Here, CAMK4 is linked to heart failure.