CAMK4 and Hypertension: Interestingly, though, CaMK4−/− mice present cognitive disorders that are typical of patients in the advanced phases of untreated hypertension,45 such as erasure of long-term memory.10 This phenotype has been ascribed to the loss of CaMK4 signaling in neurons of CaMK4−/− mice but also can be worsened by chronic exposure to increased BP levels.