To ascertain whether CaMKIV signaling is involved in endothelial dysfunction, a hallmark of the hypertensive state,11–14 we used a murine model of genetic deletion of CaMK4. Finally, a population study was carried out in normotensive and hypertensive patients to investigate the effects of the CaMK4 rs10491334 SNP in humans. This evidence concerns the gene CAMK4 and endothelial dysfunction.