The results of genetic ablation of Arg‐II on atherosclerosis development in our present study are in agreement with a recent report by Ryoo et al.25 It is important to point out that in their study, a pharmacological approach was taken to assess the effect of an arginase inhibitor on atherosclerosis development in ApoE−/− mice, whereas Arg‐II−/− mice were used to evaluate the role of Arg‐II in atherogenic diet–induced endothelial dysfunction. This evidence concerns the gene APOE and atherosclerosis.