Moreover, mRNA levels of the macrophage marker F4/80, CD11c, and the inflammatory mediators MCP1 and IL6 in epididymal fat as assessed by qRT‐PCR were increased by HF feeding in wild‐type mice; the increase was prevented or markedly blunted in Arg‐II−/− mice fed the HF diet (Figure 6E). The gene discussed is CCL2; the disease is hydrops fetalis.