Indeed, the obesity‐associated macrophage infiltration in wild‐type animals on the HF diet, as assessed by confocal microscopic immunofluorescence staining of the pan‐macrophage marker F4/80 and the proinflammatory macrophage marker CD11c, was suppressed in virtually all of the examined organs, including epididymal fat (Figure 6C), soleus muscle, liver, pancreas, heart, and kidney in the Arg‐II−/− mice (Figure 7). Here, ITGAX is linked to obesity due to melanocortin 4 receptor deficiency.