Next, we examined whether the decreased inflammation by Arg‐II gene disruption affects another important chronic inflammatory disease: atherosclerosis.4,33 For this purpose, we interbred Arg‐II−/− mice with atherosclerosis‐prone ApoE−/− mice34 and obtained ApoE−/−Arg‐II−/− mice. This evidence concerns the gene APOE and atherosclerosis.