In our community-based sample, we observed an association between new-onset type 2 diabetes and biomarkers associated with inflammation (CRP, fibrinogen, interleukin-6, monocyte-chemoattractant protein-1, and tumor necrosis receptor factor 2), endothelial dysfunction (intercellular adhesion molecule), and oxidative stress (urinary isoprostanes) after adjustment for age, sex, and cohort. This evidence concerns the gene CRP and endothelial dysfunction.