A sizable number of available studies have demonstrated an association between CRP, fibrinogen, interleukin-6, tumor necrosis factor-α, tumor necrosis factor-α receptor 2, and interleukin-18 and the new onset of diabetes.10–20 However, less has been reported about their ability to improve the discriminatory power of models containing well-established diabetes risk factors. The gene discussed is IL18; the disease is diabetes mellitus.