We chose 12 biomarkers representing multiple inflammatory pathways, including inflammation (C-reactive protein [CRP], interleukin-6, monocyte chemoattractant protein-1, tumor necrosis factor receptor 2, osteoprotegerin, and fibrinogen), endothelial dysfunction (intercellular adhesion molecule), vascular damage (CD40-ligand, P-selectin, and lipoprotein-associated phospholipase A2), and oxidative stress (urinary isoprostanes). The gene discussed is TNFRSF1B; the disease is endothelial dysfunction.