In addition, gap junctions play an integral role in the conductance properties of the myocardium, and alterations in the number and density of connexin 43–labeled gap junctions at the intercalated disc have been reported in human LVH.24 We characterized the nature and extent of interstitial remodeling in a postmortem evaluation of patients with isolated LVH and SCD, including alterations in the expression of collagen types I and III, as well as distribution of connexin 43–labeled gap junctions. Here, GJA1 is linked to Schnyder corneal dystrophy.