Myocardial collagen consists primarily of type I and type III collagen, and in animal models LVH has been shown to be associated with an early increase in the amount of type I collagen with a resultant alteration in the type I : type III collagen ratio.23,36 Previous studies have demonstrated elevated serum markers of both type I and type III collagen in human hypertensive heart disease,34,37–39 but there had been a lack of studies identifying the relative tissue distribution of these collagen subtypes in ventricular hypertrophy in humans, especially in the context of SCD. The gene discussed is SGCG; the disease is Schnyder corneal dystrophy.