Myocardial collagen consists primarily of type I and type III collagen, and in animal models LVH has been shown to be associated with an early increase in the amount of type I collagen with a resultant alteration in the type I : type III collagen ratio.23,36 Previous studies have demonstrated elevated serum markers of both type I and type III collagen in human hypertensive heart disease,34,37–39 but there had been a lack of studies identifying the relative tissue distribution of these collagen subtypes in ventricular hypertrophy in humans, especially in the context of SCD. Here, SGCG is linked to hypertensive heart disease.