A single variant in SLCO1B1, which encodes a hepatic uptake transporter, has been associated with a 17-fold increased risk of myopathy with high-dose (80 mg/d) simvastatin (see later); the finding was replicated albeit with lower odds ratios at a dose of 40 mg/d.29 Thus, the SLCO1B1 variant could potentially be used to identify susceptible individuals in whom to avoid the use of high-dose simvastatin; the recent US Food and Drug Administration relabeling of the drug (to avoid the 80-mg/d dose altogether) should also reduce population risk. The gene discussed is SLCO1B1; the disease is myopathy.