The TTR gene is synthesized in the liver, and several point mutations are described (see the Table 1), but the most common is the Val122Ile mutation.28,29 In a large autopsy study that included individuals with cardiac amyloidosis, the TTR Val122Ile allele was present in 3.9% of all African Americans and 23% of African Americans with cardiac amyloidosis. The gene discussed is TTR; the disease is cardiac amyloidosis.