There appears to be an association between wild-type ATTR and history of myocardial infarctions, G/G (Val/Val) exon 24 polymorphism in the alpha2-macroglobulin (alpha2M), and the H2 haplotype of the tau gene36; the association of tau with Alzheimer's disease raises interesting questions as both are amyloid-associated diseases of aging. This evidence concerns the gene MAPT and Alzheimer disease.