After additional adjustment for the potential intermediate exposure, diabetes, the HDL-C with apoC-III was no longer associated with the risk of CHD (RR per SD=1.02 [95% CI, 0.88–1.18]), whereas an inverse trend remained for HDL-C without apoC-III (RR per SD=0.79 [95% CI, 0.62–1.01]; Table 3). Here, APOC3 is linked to diabetes mellitus.