Therefore, the identification of a correlation between a specific memory T-cell subset that lost CCR7 receptor (TEM) with atherosclerosis and at the same time, the association with LDL cholesterol levels, support the intriguing interaction between LDL cholesterol, expansion of TEM, and atherosclerosis.5 Indeed, experimental models have shown that CD4+T cells recognize epitopes on native ApoB100 protein. Here, CD4 is linked to atherosclerosis.