TNFRSF8 and anaplastic large cell lymphoma: After directly mixing individual siRNAs and aptamers with PEI to form an average ∼140 nm hydrodynamic diameter, the targeted nanocomplexes specifically silenced ALK gene expression and induced growth arrest and apoptosis in CD30-expressing anaplastic large cell lymphoma (ALCL) cells (Zhao et al., 2011).