(6) shRNA-nanoparticles delivery: Bcl-xL shRNA-loaded covalent aptamer-Dox-PEI conjugates (PSMA-positive LNCaP cells); AR shRNA-loaded A10 aptamer – polymer conjugates (xenograft models with different prostate cancer cell lines: 22RV1, LAPC-4, and LNCaP). The gene discussed is BCL2L1; the disease is Familial prostate cancer.