(6) shRNA-nanoparticles delivery: Bcl-xL shRNA-loaded covalent aptamer-Dox-PEI conjugates (PSMA-positive LNCaP cells); AR shRNA-loaded A10 aptamer – polymer conjugates (xenograft models with different prostate cancer cell lines: 22RV1, LAPC-4, and LNCaP). This evidence concerns the gene AR and prostate carcinoma.