Although high levels of WNT2, WNT7B and WNT10B are reported to activate WNT/β-catenin signalling (Cawthorn et al, 2011; Cheng et al, 2008; Pu et al, 2009), several studies report a reduction in nuclear β-catenin staining in high-risk melanoma patients (Chien et al, 2009b; De Panfilis et al, 2009; Kageshita et al, 2001; Maelandsmo et al, 2003). This evidence concerns the gene WNT2 and melanoma.