Benign nevi express high levels of WNT transcripts including WNT2, WNT5A, WNT5B, WNT7B and WNT10B. These WNT ligands are also highly expressed in melanomas characterized by small and uniform cells, while WNTs are heterogeneously expressed in melanomas characterized by large, pleomorphic cells (Pham et al, 2003). The gene discussed is WNT5B; the disease is melanoma.