The Kaplan-Meier analysis showed that the patients with higher TRA16 expression had significantly shorter overall survival than those with lower TRA16 expression (P=0.0348) (Fig. 1E), similarly to the standard clinical prognostic factors of TNM stage, lymph node metastasis, and tumor differentiation. Here, NR2C2AP is linked to metastatic malignant neoplasm in the lymph nodes.