In contrast, the IBIS model includes extended family history, BRCA1/2 genetic status with nongenetic risk factors such as age, age at menarche, parity, age at first live birth, age at menopause, history of hormone replacement therapy use, history of hyperplasia/atypical hyperplasia, history of lobular carcinoma in situ, height and body mass index (BMI). This evidence concerns the gene BRCA1 and breast carcinoma.