The variables gender, carrier of the APOE ε4 allele, solitary living, medication use (antihypertensive/cardiac therapy, anti-diabetic drugs, lipid-lowering agents, estrogens, anti-psychotics or anxiolytics/sedatives/hypnotics), age at onset (or duration of AD), years of education, type of ChEI agent, drug dose and the interaction effects of gender × ADL ability, age × ADL ability or type of ChEI × dose were not significant when included in the models. This evidence concerns the gene APOE and Alzheimer disease.