A recent study by Gerami et al. with a new probe set including CDKN2A (9p21), RREB1 (6p25), MYC (8q24), and CCND1 (11q13) that allows also for better control of tetraploidy, revealed a sensitivity of 94% and specificity of 98% for melanoma; thus, demonstrating a marked improvement in diagnostic value [35]. This evidence concerns the gene CDKN2A and melanoma.