CCR2 and Alzheimer disease: In addition, CCR2 deficiency specifically in bone marrow cells also enhanced AD physiopathology in APPSwe/PS1 mice (Mildner et al., 2011; Naert and Rivest, 2012) and these effects were prevented by the transplantation of competent CCR2 hematopoietic stem cells (Naert and Rivest, 2012).