Acute schistosomiasis is also thought to be a reaction provoked by eggs, aswell as by migrating schistosomulae [12].IgE-mediated inflammation, triggered by egg allergen-like antigens such as SmTAL2, couldplay a role in this and could also occur in very young children in schistosomiasis-endemicareas. The gene discussed is IGHE; the disease is schistosomiasis.