Collectively, these findings have several implications: (a) miR-10b* down-regulation has a profound impact on breast cancer proliferation by disabling proper cell cycle regulation; (b) the expression of BUB1, PLK1 and CCNA2 proteins, whose respective transcripts are targets of miR-10b*, is dysregulated in different human cancers. Here, CCNA2 is linked to breast carcinoma.