All the down-regulated genes, in this Panel 3 showed their significant up-regulation in most of many types of cancers (TGM2 [63,64], CSNK1A1 [65], CTNNA1 [66], NAMPT/Visfatin [67], TNFRSF1A [68], ETS1 [41], SRC-1 [69], FN1 [70], APLP2 [71], DMBT1/SAG [64], AIB1 [72], AZIN1 [72]). The gene discussed is TGM2; the disease is cancer.