Barnes et al. [42] have reported that a late-life dementia risk index, composed of age, cognitive test performance, body mass index, apolipoprotein E ε4 alleles, cerebral white matter disease, ventricular enlargement, internal carotid artery thickening, history of bypass surgery, slow physical performance, and lack of alcohol consumption, can accurately stratify older adults into those with low, moderate, and high risk of developing dementia. Here, APOE is linked to dementia.