Under such situations, a panel of immunohistochemical stains can be useful in differentiating SCC from various other small-cell neoplasms [5].In practical work-up of SCC, immunohistochemistry is useful to discern SCC from high-grade lymphoma, SCC labels with antibodies to high molecular weight cytokeratins, but not with antibodies to leukocyte common antigen (CD45) [18]. Here, PTPRC is linked to lymphoma.