TNFSF10 and familial pancreatic carcinoma: Another study demonstrated that the treatment with dihydroartemisinin, a semisynthetic derivative of artemisinin, with antitumor activity and Apo2 ligand or tumor necrosis factor-related apoptosis-inducing ligand (Apo2L/TRAIL) increased the apoptotic effect in human pancreatic cancer cells through reactive oxygen species-mediated upregulation of DR5 [146].