According to these results, the treatment with the multiple receptor tyrosine kinase inhibitor, AEE788, together with the histone deacetylase inhibitors (LBH589, LAQ824, and trichostatin A) results in synergistic induction of apoptosis in non-small-cell lung cancer (MV522, A549), ovarian cancer (SKOV-3), and leukemia (K562, Jurkat, and ML-1) cells and in OV202hp cisplatin-resistant human ovarian cancer cells. Here, NTRK1 is linked to ovarian carcinoma.