In addition to these inflammatory disorders, NOD2 SNPs 8, 12, and 13 have also been correlated with an increased risk of malignant diseases such as colorectal [58], gastric [59], breast, and lung cancer [60] as well with the incidence of non-hodgkin's lymphoma [61], although in most of these studies, the detrimental effects of NOD2 genotype were limited to the presence of SNP 13. Here, NOD2 is linked to lung cancer.