The signaling between Slit2 and its binding partner, Robo 1, inhibits glioma cell migration in vitro and in vivo by inactivating CDC42-GTP [39], a Rho GTPase which induces the complexing of WASp and the Arp2/3 complex with actin to promote podosome formation. The gene discussed is ACTR2; the disease is central nervous system cancer.