Additionally, the expression of Pim-1 was significantly correlated to the differentiation degree, lymph node metastasis, distant metastasis and clinical staging in NSCLC tissues (P<0.01), but no correlations were observed between the expression of Pim-1 and other studied clinico-pathological parameters (P>0.05, Table 2). This evidence concerns the gene PIM1 and metastatic malignant neoplasm in the lymph nodes.