SPP1 and non-small cell lung carcinoma: Although all analyses were univariate, the present study showed that the OPN, αvβ3 and Pim-1 proteins are frequently overexpressed in NSCLC and are associated with some clinicopathologic variables which are of known prognostic importance in NSCLC, suggesting that they may play an important role in the development and/or progression of NSCLC.