Although these attenuated VACV strains exert good safety and immunogenicity profiles, the development of more efficient candidate vectors that enhance the magnitude, breadth, polyfunctionality and durability of the immune response against heterologous antigens is needed, especially after the 31.2% of protection against HIV infection obtained in the recent phase III clinical trial (RV144) in Thailand using a combination of a recombinant ALVAC and the protein gp120 [1]. The gene discussed is ITIH4; the disease is HIV infectious disease.