For example, in mouse models of CRC and several human colon cancer cell lines including H508 and SNU-C4 cells used in this study, we showed that cholinergic muscarinic receptors cross-talk with EGFR to stimulate cell proliferation, tumor growth and invasion [13], [16], [31], [32], [33], [34]. This evidence concerns the gene EGFR and colonic neoplasm.