Among a total of 107 tissue samples from JHH including 54 PCa samples and 53 normal tissues (51 matched pairs), we observed the AOX1 gene promoter to be heavily hypermethylated in PCa samples compared with normal tissues at all of the 34 tested CpG sites (mean methylation in all 34 CpG sites: PCa vs. normal = 0.73 vs. 0.07, Figure 2A and Table S6); these differences were statistically significant (FDR adjusted P<8.8×10−11). The gene discussed is AOX1; the disease is posterior cortical atrophy.