SPON2 and posterior cortical atrophy: The result of bisulfite sequencing showed hypomethylation of the SPON2 gene promoter in PCa samples compared with normal tissues, and these differences were statistically significant in 25 out of 27 tested CpG sites (mean methylation difference between PCa samples and normal tissues: –0.1 ∼ –0.27, Figure 3 and Table S7).