The same vector-containing clone eventually transformed to AML five years following transplantation, and each tumor cell was shown to contain two vector insertions, one localized 20 kb upstream of the CDw92 gene on chromosome 9, and the second localized in the first intron of BCL2A1 on chromosome 15 [2], a gene belonging to the anti-apoptotic BCL2 family not previously linked to myeloid leukemia. Here, BCL2A1 is linked to acute myeloid leukemia.