It is, therefore, interesting to find that a high Lp-PLA2 activity was associated with a worse CV prognosis, both in terms of major CV events and of acute coronary syndromes (Fig. 4), independent from all major CV risk factors, as shown by the consistent results of univariate Kaplan-Meier analysis and of the propensity score matching. This evidence concerns the gene PLA2G7 and acute coronary syndrome.