BIRC5 and breast cancer: Moreover, Mertens-Talcott et al. reported that in breast cancer cells, transfection of antisense miR-27a lead to increased expression of Zinc finger and BTB domain containing 10 (ZBTB10)( a putative Sp repressor) and these responses were accompanied by decreased expression of Sp-dependent survival and angiogenic genes, including survivin, vascular endothelial growth factor (VEGF), and VEGF receptor 1 (VEGFR1) [18].