Mertens-Talcott et al. reported that in breast cancer cells, transfection of antisense miR-27a lead to increased expression ZBTB10 and these responses were accompanied by decreased expression of survivin, Moreover, survivin is a structurally unique member of the inhibitor of apoptosis protein family that suppresses apoptosis and regulates cell division. The gene discussed is ZBTB10; the disease is breast cancer.