Our findings suggested that the skewed production of IL-6 and TGFβ in the salivary glands of SS patients may shift the milieu to one more favorable for the propagation of Th17 cells, with correspondingly fewer Foxp3+ Treg cells, and may foster a pathogenic milieu that may be causative and predictive of infiltrative injury in SS patients. This evidence concerns the gene FOXP3 and synovial sarcoma.