The identified 13 demethylated genes including WNT8B, DCC, DACT1, E2F3, NCOA4, HDAC1, PIAS3, ATF3, ZBTB33, LHX9, FASLG, TRAF3, and PIK3R2), are critical for pathogenesis of MDS. This evidence concerns the gene HDAC1 and myelodysplastic syndrome.