PIK3R2 and myelodysplastic syndrome: The identified 13 demethylated genes including WNT8B, DCC, DACT1, E2F3, NCOA4, HDAC1, PIAS3, ATF3, ZBTB33, LHX9, FASLG, TRAF3, and PIK3R2), are critical for pathogenesis of MDS.