Combinations of other stimuli such as IL-2 plus IL-7, IL-2 plus IL-12, or IL-2 plus TCR-CD3 engagement also reverse the immunosuppressed state of pleural effusion T-cells; remarkably, cytolysis of autologous tumor cells is mainly mediated by CD8+ T-cells [94]. The gene discussed is CD8A; the disease is Pleural effusion.